Article

Modelling human zygotic genome activation in 8C-like cells <i>in vitro</i>

2021-10-29

Abstract excerpt

The remodelling of the epigenome and transcriptome of the fertilised oocyte to establish totipotency in the zygote and developing embryo is one of the most critical processes in mammalian embryogenesis. Zygotic or embryonic genome activation (ZGA, EGA) in the 2-cell embryo in mouse, and the 8-cell embryo in humans, constitutes the first major wave of transcription. Failure to initiate ZGA leads to developmental de...

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Literature Corpus work: 722a0da5-0bb3-5b88-9c92-677b374b935f
DOI: 10.1101/2021.10.28.466259

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