Article

Modeling Post-Gastrula Development via Bidirectional Pluripotent Stem Cells

2025-06-29

Abstract excerpt

<h4>Summary</h4> The absence of stem cells capable of efficiently generating both trophoblast and epiblast lineages has hindered precise recapitulation of embryonic development. Through high-content chemical screening, we established an AL medium to generate mouse and human bidirectional pluripotent stem cells (BPSCs) characterized by concurrent OCT4/CDX2 expression. Mouse BPSCs demonstrated high plastic differen...

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Literature Corpus work: 88648c06-fc44-524a-bad0-43827028c154
DOI: 10.1101/2025.06.28.662107

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