Article

Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment

2016-05-08

Abstract excerpt

<h4>Summary</h4> We leveraged IDH wild type glioblastomas and derivative neurospheres to define tumor-intrinsic transcription phenotypes. Transcriptomic multiplicity correlated with increased intratumoral heterogeneity and tumor microenvironment presence. In silico cell sorting demonstrated that M2 macrophages/microglia are the most frequent type of immune cells in the glioma microenvironment, followed by CD4 T l...

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Literature Corpus work: 766aab0d-09bf-560c-bd99-f6feca6ae537
DOI: 10.1101/052076

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