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Article

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

2018-03-14

Abstract excerpt

<h4>Background</h4> Major Depressive Disorder (MDD) is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome, and growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide an important route for identification of...

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Literature Corpus work
ea91e056-cd27-5d1e-8ab2-3c52d52d8f94
DOI
10.1101/282053
Open publication

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