Article

Mutation of a single cysteine in CaMKIIδ protects the heart from ischemia-reperfusion Injury

2026-04-30

Abstract excerpt

CaMKIIδ is the dominant isozyme of Ca 2+ /calmodulin-dependent protein kinase II in the heart. Under certain pathological conditions, it can be oxidized, causing a constitutive activation that can lead to cardiac failure. We recently showed that, in purified CaMKIIδ exposed to oxidative conditions, a disulfide link formed between Cys273 and Cys290 causes this autonomous activation. Cys273 has a low pKa that facil...

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Literature Corpus work: 37be5691-1992-50c5-876e-c967bd7818c2
DOI: 10.64898/2026.04.27.721066

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