Article
Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2006
Heaton Daniel A, Lei Ming, Li Dan, Golding Simon, Dawson Tom A, Mohan Ravi M, Paterson David J
Abstract excerpt
Hypertension is associated with abnormal neurohumoral activation. We tested the hypothesis that beta-adrenergic hyperresponsiveness in the sinoatrial node (SAN) of the spontaneously hypertensive rat occurs at the level of the L-type calcium current because of altered cyclic nucleotide-dependent signaling. Furthermore, we hypothesized that NO, a modulator of cGMP and cAMP, would normalize the beta-adrenergic...
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