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Article

Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism

1 May 2019

Abstract excerpt

Flaviviruses such as yellow fever virus (YFV), Zika virus (ZIKV), and dengue virus (DENV) are important human pathogens. A common flavivirus trait is the antagonism of interferon (IFN) signaling to enhance viral replication and spread. We report that like ZIKV NS5 and DENV NS5, YFV NS5 binds human STAT2 (hSTAT2) but not mouse STAT2 (mSTAT2), a type I IFN (IFN-α/β) pathway component. Additionally, we show that...

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Identifiers

PMID: 31043530
DOI: 10.1128/jvi.00151-19

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