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Article

Loss of STAT2 may be dangerous in a world filled with viruses.

The Journal of clinical investigation - 15 Jun 2023

Jordan Michael B

Abstract excerpt

Type I IFNs, a family of cytokines that signal through a single receptor and signaling mechanism, were originally named for their ability to interfere with viral replication. While type II IFN (IFN-γ) largely protects against intracellular bacteria and protozoa, type I IFNs largely protect from viral infections. Inborn errors of immunity in humans have demonstrated this point and its clinical relevance with...

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Identifiers

PMID: 37317971
DOI: 10.1172/JCI170886
PMCID: PMC10266770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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