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Article

Clinicogenomic Landscape and Function of PIK3CA, AKT1, and PTEN Mutations in Breast Cancer.

JCO precision oncology - 1 Apr 2026

Tao Jacqueline J, Sisoudiya Saumya D, Tukachinsky Hanna, Schrock Alexa B, Ebot Ericka M, Sivakumar Smruthy, Sokol Ethan S, Vasan Neil

Abstract excerpt

PURPOSE: To comprehensively characterize the clinical and genomic landscapes of PIK3CA, AKT1, and PTEN alterations and examine their functional and therapeutic implications in AKT-driven breast cancer. METHODS: Comprehensive genomic profiling of 51,767 breast tumors was performed using FoundationOne CDx or FoundationOne. We examined the genomic landscape of PIK3CA, AKT1, and PTEN alterations and their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41955551
DOI: 10.1200/PO-25-00609
PMCID: PMC13086116

Genes

PTEN
PIK3CA
AKT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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