Article

JMJD5 regulates metabolism by hydroxylating ISY1, and regulating the Arginine Methyltransferase PRMT6

2025-09-29

Abstract excerpt

2-Oxoglutarate-dependent dioxygenases (2OGDDs) employ molecular oxygen, 2-oxoglutarate, and ferrous iron to catalyse two-ectron oxidations. This dependency enables some 2OGDD to act as sensors of cellular metabolic states, driving crucial functions when oxygen or metabolic homeostasis is perturbed, including adaptation to low oxygen, epigenetic control of gene transcription, and the reshaping of metabolic pathways...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea5cad00-7ad4-50a3-92a0-795f89a7dee6
DOI: 10.1101/2025.09.27.678987

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

JMJD5 regulates metabolism by hydroxylating ISY1, and regulating the Arginine Methyltransferase PRMT6DOI 10.1101/2025.09.27.678987Read

Inactivation of a protein hydroxylase complex impairs replication fork restart in cancer and neurodevelopmental disordersSemantic proximity Read

JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by HydroxylationSemantic proximity Read

Rare insights into cancer biology.Semantic proximity Read

Distinct RNA N-Demethylation Pathways Catalyzed by Non-Heme Iron ALKBH5 and FTO Enzymes Enable Regulation of Formaldehyde Release RatesSemantic proximity Read

Radical S-Adenosylmethionine Enzymes in Human Health and Disease.Semantic proximity Read

A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the SpotlightSemantic proximity Read

Metabolic Rewiring in the Face of Genomic Assault: Integrating DNA Damage Response and Cellular MetabolismSemantic proximity Read

JMJD family proteins in cancer and inflammationSemantic proximity Read

The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress.Semantic proximity Read

Dual-stress-responsive-pathways prevent HCC initiation via p53 suppression of MTHFD1L-RNA m6A-elicited autonomous growth and immune evasionSemantic proximity Read

Identification of biomarkers and pathways of mouse embryonic fibroblasts with the dysfunction of mitochondrial DNASemantic proximity Read

Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinomaSemantic proximity Read