Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radical S-Adenosylmethionine Enzymes in Human Health and Disease.

Annual review of biochemistry - 2 Jun 2016

Landgraf Bradley J, McCarthy Erin L, Booker Squire J

Abstract excerpt

Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishing array of complex and chemically challenging reactions across all domains of life. Of approximately 114,000 of these enzymes, 8 are known to be present in humans: MOCS1, molybdenum cofactor biosynthesis; LIAS, lipoic acid biosynthesis; CDK5RAP1, 2-methylthio-N(6)-isopentenyladenosine biosynthesis; CDKAL1, methylthio-N(6)-threonylcarbamoyladenosine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon-Carbon Lyases
Share to Heart Defects, Congenital
Share to Histone Acetyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iron-Sulfur Proteins

Share to Neurodegenerative Diseases

Share to Oxidoreductases Acting on CH-CH Group Donors

Share to S-Adenosylmethionine

Share to tRNA Methyltransferases

Source

Identifiers

PMID: 27145839
DOI: 10.1146/annurev-biochem-060713-035504

Genes

CDKAL1
ELP3
LIAS
MOCS1
RSAD1
TYW1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radical S-Adenosylmethionine Enzymes in Human Health and Disease.PMID 27145839Read ↗

Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.Semantic proximity Read ↗

Biological functions of m6A methyltransferasesSemantic proximity Read ↗

Accumulation of an unprecedented 5′-deoxyadenos-4′-yl radical unmasks the kinetics of the radical-mediated C-C bond formation step in MoaA catalysisSemantic proximity Read ↗

Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26.Semantic proximity Read ↗

Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapySemantic proximity Read ↗

Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.Semantic proximity Read ↗

Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress SurvivalSemantic proximity Read ↗

Profiling the compendium of changes in Saccharomyces cerevisiae due to mutations that alter availability of the main methyl donor S-Adenosylmethionine.Semantic proximity Read ↗

The 'golden age' of DNA methylation in neurodegenerative diseases.Semantic proximity Read ↗

Methionine adenosyltransferase structure and function studies : the novel role of a gating loop and a disease-causing residue in enzyme catalysisSemantic proximity Read ↗

JMJD5 regulates metabolism by hydroxylating ISY1, and regulating the Arginine Methyltransferase PRMT6Semantic proximity Read ↗

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.