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Article

The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress.

Molecular and cellular biology - 1 Dec 2008

Polytarchou Christos, Pfau Raymond, Hatziapostolou Maria, Tsichlis Philip N

Abstract excerpt

The histone H3 demethylase Ndy1/KDM2B protects cells from replicative senescence. Changes in the metabolism of reactive oxygen species (ROS) are important for establishing senescence, suggesting that Ndy1 may play a role in redox regulation. Here we show that Ndy1 protects from H(2)O(2)-induced apoptosis and G(2)/M arrest and inhibits ROS-mediated signaling and DNA damage, while knockdown of Ndy1 has the opposite...

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Identifiers

PMID: 18838535
DOI: 10.1128/MCB.00688-08
PMCID: PMC2593427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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