Article

Dual-stress-responsive-pathways prevent HCC initiation via p53 suppression of MTHFD1L-RNA m6A-elicited autonomous growth and immune evasion

2026-04-30

Abstract excerpt

<title>Abstract</title> <p> Hepatocellular carcinoma (HCC) originates from damaged hepatocytes in chronic liver injury. Though HCC development requires oncoproteins-mediated p53 inhibition, both genetic deletion and continous activation of p53 specifically in mouse hepatocytes are shown to promote liver tumorigenesis, suggesting that chronic liver injury firstly activates p53, and p53 activity needs to be dynami...

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Literature Corpus work: 87dd1867-1ef6-5221-b29a-44d8599f7a25
DOI: 10.21203/rs.3.rs-9474831/v1

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