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Article

JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation

25 Mar 2014

Abstract excerpt

Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular activity of JMJD6 is still not clearly defined and its biological function is still largely unexplored. Here we report that JMJD6 is physically associated with the tumor suppressor p53. We demonstrated that JMJD6 acts as an α-ketoglutarate- and...

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PMID: 24667498
DOI: 10.1371/journal.pbio.1001819

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JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by HydroxylationPMID 24667498Read ↗

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Computational and Mass Spectrometry-Based Approach Identify Deleterious Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) in JMJD6.Semantic proximity Read ↗

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HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism.Semantic proximity Read ↗

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