Back to search

Article

Organelle proteomics reveals novel metabolic vulnerabilities in FLT3-ITD cells

2026-01-19

Abstract excerpt

<h4>Summary</h4> In acute myeloid leukemia (AML), the insertion site of internal tandem duplications (ITDs) within the FLT3 gene critically determines the sensitivity to tyrosine kinase inhibitors (TKIs). Despite recent advances, patients harboring ITDs in the tyrosine kinase domain (TKD) still lack effective therapeutic options. To elucidate the molecular basis underlying the differential TKI sensitivity of FLT...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ea461694-ddf1-5b4a-9605-05e0fbfb284e
DOI
10.64898/2026.01.19.700272
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Organelle proteomics reveals novel metabolic vulnerabilities in FLT3-ITD cellsDOI 10.64898/2026.01.19.700272
Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.Semantic proximity
A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patientsSemantic proximity
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.Semantic proximity
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cellsSemantic proximity
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.Semantic proximity
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.Semantic proximity
A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients.Semantic proximity
Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid LeukemiaSemantic proximity
ZMAT3 alleviates cell death of Fanconi Anemia deficient cells by modulating sphingolipid metabolism and ferroptosis.Semantic proximity
Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activitySemantic proximity
ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid LeukemiaSemantic proximity
FLCN-mutated oncocytic tumor in the thyroid defines a biologically distinct subset characterized by metabolic remodeling and canonical oncogenic signaling suppression.Semantic proximity
Select a neighboring publication to make it the new centre.