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FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.

Scientific reports - 22 Nov 2021

Yamawaki Kouhei, Shiina Isamu, Murata Takatsugu, Tateyama Satoru, Maekawa Yutarou, Niwa Mariko, Shimonaka Motoyuki, Okamoto Koji, Suzuki Toshihiro, Nishida Toshirou, Abe Ryo, Obata Yuuki

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) in hematopoietic cells binds to its ligand at the plasma membrane (PM), then transduces growth signals. FLT3 gene alterations that lead the kinase to assume its permanently active form, such as internal tandem duplication (ITD) and D835Y substitution, are found in 30-40% of acute myelogenous leukemia (AML) patients. Thus, drugs for molecular targeting of FLT3 mutants have been...

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PMID: 34811450
DOI: 10.1038/s41598-021-02221-2
PMCID: PMC8608843

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