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A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients.

Leukemia - 1 Feb 2023

Massacci Giorgia, Venafra Veronica, Latini Sara, Bica Valeria, Pugliese Giusj Monia, Graziosi Simone, Klingelhuber Felix, Krahmer Natalie, Fischer Thomas, Mougiakakos Dimitrios, Boettcher Martin, Perfetto Livia, Sacco Francesca

Abstract excerpt

The insertion site of the internal tandem duplications (ITDs) in the FLT3 gene affects the sensitivity to tyrosine kinase inhibitors (TKIs) therapy in acute myeloid leukemia (AML). Patients with the ITD in the tyrosine kinase domain lack effective therapeutic options. Here, to identify genotype-driven strategies increasing the TKI therapy efficacy, we developed SignalingProfiler, a strategy supporting the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36509894
DOI: 10.1038/s41375-022-01785-w
PMCID: PMC9898030

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