Article

ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid Leukemia

2024-10-15

Abstract excerpt

<title>Abstract</title> <p>Deregulation of lipid metabolism has been shown to be involved in leukemogenesis and disease progression of acute myeloid leukemia (AML), yet vulnerabilities within the lipidome remain largely unexplored. Through comprehensive analysis of CRISPR-Cas9 screening data, we identified a specific dependency of a subset of AML cell lines on the gene acyl-CoA synthetase long chain family member...

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Literature Corpus work: 4ee8b8e9-525b-519e-a78a-40e26fb309b2
DOI: 10.21203/rs.3.rs-4924771/v1

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