Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.

Blood - 13 Oct 2016

Dany Mohammed, Gencer Salih, Nganga Rose, Thomas Raquela J, Oleinik Natalia, Baron Kyla D, Szulc Zdzislaw M, Ruvolo Peter, Kornblau Steven, Andreeff Michael, Ogretmen Besim

Abstract excerpt

Signaling pathways regulated by mutant Fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD), which mediate resistance to acute myeloid leukemia (AML) cell death, are poorly understood. Here, we reveal that pro-cell death lipid ceramide generation is suppressed by FLT3-ITD signaling. Molecular or pharmacologic inhibition of FLT3-ITD reactivated ceramide synthesis, selectively inducing mitophagy and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzimidazoles
Share to Ceramides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Dynamins

Share to fms-Like Tyrosine Kinase 3

Share to Mice, Inbred NOD

Share to Mitophagy

Share to Piperidines

Source

Open in PubMed Open full text

Identifiers

PMID: 27540013
DOI: 10.1182/blood-2016-04-708750
PMCID: PMC5064718

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.PMID 27540013Read ↗

Potential role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights.Semantic proximity Read ↗

Organelle proteomics reveals novel metabolic vulnerabilities in FLT3-ITD cellsSemantic proximity Read ↗

Mitochondrial abnormalities as a target of intervention in acute myeloid leukemiaSemantic proximity Read ↗

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid LeukemiaSemantic proximity Read ↗

Autophagy a Close Relative of AML BiologySemantic proximity Read ↗

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells.Semantic proximity Read ↗

Autophagy inhibition impairs leukemia stem cell function in FLT3-ITD AML but has antagonistic interactions with tyrosine kinase inhibition.Semantic proximity Read ↗

Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a phase II trial.Semantic proximity Read ↗

Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugsSemantic proximity Read ↗

Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia.Semantic proximity Read ↗

Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3-ITD-driven acute myeloid leukemia.Semantic proximity Read ↗

Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.