Article

Tau local structure shields amyloid motif and controls aggregation propensity

2018-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene ( MAPT ) correlate with aggregation propensity and cause dominantly inherited tauopathies, but their biophysical mechanism driving amyloid formation is poorly understood. Many disease-associated mutations localize within tau’s repeat domain at inter-repea...

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Literature Corpus work: 7102d8b7-b6c7-5810-a59b-689619f5a3ce
DOI: 10.1101/330266

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