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scEC&T-seq: a method for parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single human cells

2023-05-24

Abstract excerpt

<title>Abstract</title> <p>Extrachromosomal DNA amplifications are common in cancer and are associated with decreased patient survival. A key feature of extrachromosomal circular DNA is its ability to be randomly mis-segregated to daughter cells promoting rapid intercellular heterogeneity. Understanding how extrachromosomal circular DNA dynamics contribute to intercellular heterogeneity remains crucial to better...

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Literature Corpus work
41809cb8-9800-553c-86cb-25946fe83c63
DOI
10.21203/rs.3.pex-2180/v1
Open publication

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