Article
O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.
Genetics - 1 Jun 2011
Mondoux Michelle A, Love Dona C, Ghosh Salil K, Fukushige Tetsunari, Bond Michelle, Weerasinghe Gayani R, Hanover John A, Krause Michael W
Abstract excerpt
In a variety of organisms, including worms, flies, and mammals, glucose homeostasis is maintained by insulin-like signaling in a robust network of opposing and complementary signaling pathways. The hexosamine signaling pathway, terminating in O-linked-N-acetylglucosamine (O-GlcNAc) cycling, is a key sensor of nutrient status and has been genetically linked to the regulation of insulin signaling in Caenorhabditis...
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