Article

All-trans retinoic acid (ATRA) reduces proliferative capacity and Brachyury levels in chordoma cells

2020-01-09

Abstract excerpt

Chordoma is a rare bone cancer for which there are no approved drugs. Surgery is the principle treatment but complete resection can be challenging due to the location of the tumours in the spine and therefore finding an effective drug treatment is a pressing unmet clinical need. A major recent study identified the transcription factor Brachyury as the primary vulnerability and drug target in chordoma. Previously,...

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Literature Corpus work: 45f75eee-f078-5b7b-b08d-b604b61f6a1a
DOI: 10.1101/2020.01.09.897314

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