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The Roles of Embryonic Transcription Factor BRACHYURY in Tumorigenesis and Progression

30 Jun 2020

Abstract excerpt

Transcription factor brachyury, with a DNA-binding T-domain, regulates posterior mesoderm formation and notochord development through binding with highly conserved palindromic consensus sequence in a variety of organisms. The absence of brachyury expression in majority of adult normal tissues and exclusive tumor-specific expression provides the potential to be developed into a novel and promising diagnostic and...

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PMID: 32695672
DOI: 10.3389/fonc.2020.00961

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