Article

AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance

2018-08-14

Abstract excerpt

The human 1q21.1 deletion of ten genes is associated with increased risk schizophrenia. The deletion involves the ß-subunit of the AMP-activated protein kinase (AMPK) complex, a key energy sensor in the cell. Although neurons have a high demand for energy and low capacity to store nutrients, the role of AMPK in neuronal physiology is poorly defined. Here we show that AMPK is important in the nervous system for mai...

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Literature Corpus work: e9e8befd-bdc3-5de9-9b88-036b0c09c5ba
DOI: 10.1101/391722

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