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Article

Wolfram syndrome 1 regulates sleep in dopamine receptor neurons by modulating calcium homeostasis.

PLoS genetics - 1 Jul 2023

Hao Huanfeng, Song Li, Zhang Luoying

Abstract excerpt

Sleep disruptions are quite common in psychological disorders, but the underlying mechanism remains obscure. Wolfram syndrome 1 (WS1) is an autosomal recessive disease mainly characterized by diabetes insipidus/mellitus, neurodegeneration and psychological disorders. It is caused by loss-of function mutations of the WOLFRAM SYNDROME 1 (WFS1) gene, which encodes an endoplasmic reticulum (ER)-resident transmembrane...

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Identifiers

PMID: 37399203
DOI: 10.1371/journal.pgen.1010827
PMCID: PMC10348591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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