Article

Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins

2023-04-21

Abstract excerpt

Metazoans inherited genes from unicellular ancestors that perform essential biological processes such as cell division, metabolism and protein translation. Functioning multicellularity requires careful control and coordination of these unicellular genes to maintain tissue integrity and homeostasis. Gene regulatory networks (GRNs) formed during metazoan evolution to regulate conserved biological processes are frequ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e97371a9-27f2-5be8-b1e5-b1831db6dc53
DOI: 10.1101/2023.04.20.537744

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular originsDOI 10.1101/2023.04.20.537744Read

Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular originsSemantic proximity Read

Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancerSemantic proximity Read

Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors.Semantic proximity Read

Shared and unique mutational gene co-occurrences in cancers.Semantic proximity Read

A network of cancer genes with co-occurring and anti-co-occurring mutations.Semantic proximity Read

Communication Breakdown and Evolution of the Cancer CellSemantic proximity Read

Loss of long-range co-expression is a common trait in cancerSemantic proximity Read

Loss of long-range co-expression is a common feature in cancerSemantic proximity Read

Loss of Long Distance Co-Expression in Lung CancerSemantic proximity Read

Pan-cancer analysis of somatic mutations and transcriptomes reveals common functional gene clusters shared by multiple cancer types.Semantic proximity Read

Analysis of pathway mutation profiles highlights collaboration between cancer-associated superpathways.Semantic proximity Read

Mutations in a set of ancient matrisomal glycoprotein genes across neoplasia predispose to disruption of morphogenetic transductionSemantic proximity Read