Article

Communication Breakdown and Evolution of the Cancer Cell

2025-08-20

Abstract excerpt

1 We studied cell-cell interactions (CCIs) in large-scale transcriptomic datasets, which showed higher co-expression in cancer compared to healthy tissues. CCIs are more co-expressed than any other type of intracellular interaction and, likewise, they are the protein-protein interaction (PPI) class that is most co-evolved in sequenced genomes. Similar trends of stricter regulation and evolutionary pressure are obs...

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Literature Corpus work: 5ca15594-6bce-5d8f-828f-e9f3777ebfec
DOI: 10.1101/2025.08.15.670478

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