Article

Mutations in a set of ancient matrisomal glycoprotein genes across neoplasia predispose to disruption of morphogenetic transduction

2022-07-01

Abstract excerpt

Misexpression and remodeling of the extracellular matrix is a canonical hallmark of cancer, although the extent of cancer-associated aberrations in the genes coding for ECM proteins and consequences thereof, are not well understood. In this study, we examined the alterations in core matrisomal genes across a set of nine cancers. These genes, especially the ones encoding for ECM glycoproteins, were observed to be m...

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Literature Corpus work: ab17b06e-5a1d-54b8-9965-9970df922ba2
DOI: 10.1101/2022.06.28.497924

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