Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors.

Abstract excerpt

Tumors of distinct tissues of origin and genetic makeup display common hallmark cellular phenotypes, including sustained proliferation, suppression of cell death, and altered metabolism. These phenotypic commonalities have been proposed to stem from disruption of conserved regulatory mechanisms evolved during the transition to multicellularity to control fundamental cellular processes such as growth and...

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