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Article

Evolution of GC-biased gene conversion by natural selection.

Genetics - 6 Aug 2025

Clessin Augustin, Joseph Julien, Lartillot Nicolas

Abstract excerpt

GC-biased gene conversion is a recombination-associated evolutionary process that biases the segregation ratio of AT:GC polymorphisms in the gametes of heterozygotes, in favor of GC alleles. This process is the major determinant of the variation in base composition across the human genome and can be the cause of a substantial burden of deleterious GC alleles. While the importance of GC-biased gene conversion in...

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Identifiers

PMID: 40510024
DOI: 10.1093/genetics/iyaf111
PMCID: PMC12341927

Genes

GC

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