Article

The GC-content at the 5’ends of human protein-coding genes is undergoing mutational decay

2024-03-14

Abstract excerpt

In vertebrates, most protein-coding genes have a peak of GC-content near their 5’ transcriptional start site (TSS). This feature promotes both the efficient nuclear export and translation of mRNAs. Despite the importance of GC-content for RNA metabolism, its general features, origin, and maintenance remain mysterious. We investigated the evolutionary forces shaping GC-content at the transcriptional start site (TSS...

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Literature Corpus work: 1e388cad-7ecd-55be-b693-71998d6dabc0
DOI: 10.1101/2024.03.12.584636

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