Article

Low memory T cells blood counts and high naïve regulatory T cells percentage at relapsing remitting multiple sclerosis diagnosis

2022-03-07

Abstract excerpt

<h4>Objective</h4> To assess the peripheral immune system of newly diagnosed relapsing remitting multiple sclerosis (RRMS) patients and compare it to healthy controls (HC). <h4>Methods</h4> Cross-sectional study with 30 treatment-naïve newly diagnosed RRMS patients, and 33 sex and age-matched HC. Their peripheral blood mononuclear cells were analysed regarding: i) thymic function surrogates [T cell receptor exci...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e94b5f00-695a-55dd-8e36-70138ac45304
DOI: 10.1101/2022.03.07.483243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low memory T cells blood counts and high naïve regulatory T cells percentage at relapsing remitting multiple sclerosis diagnosisDOI 10.1101/2022.03.07.483243Read

Deficiency of CD8 <sup>+</sup> effector memory T cells is an early and persistent feature of multiple sclerosisSemantic proximity Read

Specific myeloid signatures in peripheral blood differentiate active and rare clinical phenotypes of multiple sclerosis.Semantic proximity Read

Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progressionSemantic proximity Read

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosisSemantic proximity Read

Regulatory T-cells in multiple sclerosis produce IL-10 in the central 1 nervous system but are activated by Epstein-Barr VirusSemantic proximity Read

Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal ModelsSemantic proximity Read

Multiple sclerosis.Semantic proximity Read

Multiparametric flow cytometric analysis of whole blood reveals changes in minor lymphocyte subpopulations of multiple sclerosis patients.Semantic proximity Read

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells.Semantic proximity Read

Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosisSemantic proximity Read

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patientsSemantic proximity Read

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosisSemantic proximity Read