The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells.

doi:10.1093/brain/awy151

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Article

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells.

Brain : a journal of neurology - 1 Jul 2018

Machado-Santos Joana, Saji Etsuji, Tröscher Anna R, Paunovic Manuela, Liblau Roland, Gabriely Galina, Bien Christian G, Bauer Jan, Lassmann Hans

Abstract excerpt

Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so far little is known regarding the phenotype and function of these infiltrating lymphocyte populations. In this study, we performed an in-depth phenotypic characterization of T and B cell infiltrates in a large set of multiple sclerosis...

Topics

Adult
Aged
B-Lymphocytes
Brain
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Demyelinating Diseases
Encephalitis
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammation

Lymphocytes

Male

Middle Aged

Multiple Sclerosis

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 29873694
DOI: 10.1093/brain/awy151
PMCID: PMC6022681

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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