Article

Regulatory T-cells in multiple sclerosis produce IL-10 in the central 1 nervous system but are activated by Epstein-Barr Virus

2024-07-30

Abstract excerpt

Regulatory T-cells (Tregs) maintain immune homeostasis, but antigens activating adaptive Tregs in human pathologies are ill-defined. EOMES + type-1 regulatory (Tr1)-like T-cells had a dysregulated homeostasis in multiple sclerosis (MS), which was related to their activation in the central nervous system (CNS). EOMES + Tr1-like cells were enriched and clonally expanded in patient’s cerebrospinal fluid (CSF) and w...

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Literature Corpus work: 3717c41b-688b-502d-aafe-bf9cb6b474cf
DOI: 10.1101/2024.07.30.605745

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