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Article

Deficiency of CD8 <sup>+</sup> effector memory T cells is an early and persistent feature of multiple sclerosis

19 May 2014

Abstract excerpt

BACKGROUND: Patients with multiple sclerosis (MS) have a deficiency of circulating CD8+ T cells, which might impair control of Epstein-Barr virus (EBV) and predispose to MS by allowing EBV-infected autoreactive B cells to accumulate in the central nervous system. Based on the expression of CD45RA and CD62L, CD4+ T cells and CD8+ T cells can be subdivided into four subsets with distinct homing and functional...

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PMID: 24842963
DOI: 10.1177/1352458514536252

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