Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression

2 Jun 2023

Abstract excerpt

Abstract Background Multiple sclerosis (MS) leads to demyelination and neurodegeneration with autoimmune responses in central nervous system. Patients begin with a relapsing–remitting (RR) course, and more than 80% of them may advance to secondary progressive MS (SPMS), which is characteristic for the gradual decline of neurological functions without demonstrated treating method to prevent. This study aims to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Sclerosis Research Studies
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37268957
DOI: 10.1186/s12974-023-02810-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progressionPMID 37268957Read ↗

Regulatory B Cells and Its Role in Central Nervous System Inflammatory Demyelinating Diseases.Semantic proximity Read ↗

Specific myeloid signatures in peripheral blood differentiate active and rare clinical phenotypes of multiple sclerosis.Semantic proximity Read ↗

Memory B Cells in Multiple Sclerosis: Emerging Players in Disease Pathogenesis.Semantic proximity Read ↗

Low memory T cells blood counts and high naïve regulatory T cells percentage at relapsing remitting multiple sclerosis diagnosisSemantic proximity Read ↗

Multiple sclerosis.Semantic proximity Read ↗

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosisSemantic proximity Read ↗

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells.Semantic proximity Read ↗

CD8<sup>+</sup>T cells in multiple sclerosisSemantic proximity Read ↗

Early multiple sclerosis activity associated with TBX21+CD21loCXCR3+ B cell expansion resembling EBV-induced phenotypes.Semantic proximity Read ↗

Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy.Semantic proximity Read ↗

Current trends in multiple sclerosis research: an update on pathogenic concepts.Semantic proximity Read ↗

Memory-biased CD8αα⁺ T cells show reduced abundance and phenotypic remodeling in SLE.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.