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Chromatin Remodeling, DNA Damage Repair and Aging

1 Sept 2012

Abstract excerpt

Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all DNA-related events. Studies on human premature aging syndromes together...

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PMID: 23633913
DOI: 10.2174/138920212803251373

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