Article

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution

2021-04-13

Abstract excerpt

Intratumoral heterogeneity (ITH) is a hallmark of cancer. The advent of single-cell technologies has helped uncover ITH in a high-throughput manner in different cancers across varied contexts. Here we apply single-cell sequencing technologies to reveal striking ITH in assumptively oligoclonal pancreatic ductal adenocarcinoma (PDAC) cell lines. Our findings reveal a high degree of both genomic and transcriptomic he...

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Literature Corpus work: e927925e-17fd-5bf9-b4ed-f12ea29a5f6b
DOI: 10.1101/2021.04.13.439717

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