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Article

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution

25 Jun 2022

Abstract excerpt

Heterogeneity is a hallmark of cancer. The advent of single-cell technologies has helped uncover heterogeneity in a high-throughput manner in different cancers across varied contexts. Here we apply single-cell sequencing technologies to reveal inherent heterogeneity in assumptively monoclonal pancreatic cancer (PDAC) cell lines and patient-derived organoids (PDOs). Our findings reveal a high degree of both...

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PMID: 35752636
DOI: 10.1038/s41467-022-31376-3

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