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Challenges in genomic analysis of model systems and primary tumors of pancreatic ductal adenocarcinoma

1 Jan 2022

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive tumor behavior and poor prognosis. Recent next-generation sequencing (NGS)-based genomic studies have provided novel treatment modes for pancreatic cancer via the identification of cancer driver variants and molecular subtypes in PDAC. Genome-wide approaches have been extended to model systems such as patient-derived xenografts (PDXs),...

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PMID: 36147673
DOI: 10.1016/j.csbj.2022.08.064

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