Article

Pancreatic cancer patient-derived organoids capture therapy response and tumor evolution

2025-04-26

Abstract excerpt

<h4>SUMMARY</h4> Patient-derived organoids (PDOs) reflect parental tumor features and may represent promising avatars for prognosticating drug response. Here, we recruited 169 patients with pancreatic cancer (PC) and established a living biobank including 83 pharmacotyped PDOs isolated from primary and metastatic, treatment-naïve and pretreated PCs. In a core facility setting, the pharmacotyping success rate was...

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Literature Corpus work: e9272e9e-3db1-51f7-a7f3-bc1a99d1f40d
DOI: 10.1101/2025.04.24.650216

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