Article

Patient-derived urachal cancer organoids for personalized drug screening

2026-01-19

Abstract excerpt

<title>Abstract</title> <p> Background Urachal cancer (UrC) is a rare, aggressive malignancy typically diagnosed at advanced stages, where systemic treatment becomes necessary. However, cytotoxic chemotherapy offers limited efficacy, and prospective clinical trials are exceedingly difficult due to the rarity of the disease. Thus, robust <italic>in vitro</italic> models are urgently needed to support precision...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 382b3f6e-2dce-597e-a9d1-e1999286aaf7
DOI: 10.21203/rs.3.rs-8245003/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Patient-derived urachal cancer organoids for personalized drug screeningDOI 10.21203/rs.3.rs-8245003/v1Read

Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatmentSemantic proximity Read

Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.Semantic proximity Read

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoidsSemantic proximity Read

Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumorsSemantic proximity Read

Pancreatic cancer patient-derived organoids capture therapy response and tumor evolutionSemantic proximity Read

Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic VulnerabilitiesSemantic proximity Read

Bladder cancer organoids as a functional system to model different disease stages and therapy responseSemantic proximity Read

Modeling colorectal cancer: A bio‐resource of 50 patient‐derived organoid linesSemantic proximity Read

Patient‐Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug ScreeningSemantic proximity Read

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug ResponsesSemantic proximity Read

Optimized large-scale longitudinal biorepository of gastroesophageal adenocarcinoma patient-derived organoids: High-fidelity models for personalized treatment to overcome resistanceSemantic proximity Read

Bladder cancer organoids as a functional system to model different disease stages and therapy responseSemantic proximity Read