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Article

Implementing cell-free DNA of pancreatic cancer patient–derived organoids for personalized oncology

2 Jul 2020

Abstract excerpt

One of the major challenges in using pancreatic cancer patient-derived organoids (PDOs) in precision oncology is the time from biopsy to functional characterization. This is particularly true for endoscopic ultrasound-guided fine-needle aspiration biopsies, typically resulting in specimens with limited tumor cell yield. Here, we tested conditioned media of individual PDOs for cell-free DNA to detect driver...

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PMID: 32614802
DOI: 10.1172/jci.insight.137809

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