Article

Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities

2025-04-17

Abstract excerpt

<h4>ABSTRACT</h4> We developed a tumor-matched, pan-cancer patient-derived organoid (PDO) platform comprising 220 PDOs from 190 patients across 15 cancer types to advance functional precision oncology. Our comprehensively characterized PDOs showed 93% histopathology concordance, 80% median genomic concordance for driver mutations, and a 0.85 median gene expression correlation with parent tumors. Gene expression i...

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Literature Corpus work: 93885561-4674-562c-969a-cfe8c4ad9064
DOI: 10.1101/2025.04.10.647635

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