Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease.

doi:10.1016/j.atherosclerosis.2025.120219

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease.

Atherosclerosis - 1 Aug 2025

Lundin Jessica I, Peters Ulrike, Hu Yao, Ammous Farah, Benjamin Emelia J, Bis Joshua C, Brody Jennifer A, Cushman Mary, Fuller Harriett, Gignoux Chris, Guo Xiuqing, Haessler Jeff, Haiman Chris, Joehanes Roby, Kasela Silva, Kenny Eimear, Lappalainen Tuuli, Levy Daniel, Liu Chunyu, Liu Yongmei, Loos Ruth J F, Matise Tara, North Kari E, Park Sungshim L, Ratliff Scott M, Reiner Alex, Rich Stephen S, Rotter Jerome I, Smith Jennifer A, Sotoodehnia Nona, Tracy Russell, Van den Berg David, Ye Ting, Zhao Wei, Raffield Laura M, Kooperberg Charles

Abstract excerpt

BACKGROUND AND AIMS: Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality worldwide, yet the underlying molecular mechanisms remain less understood. Chronic low-grade inflammation is a complex immune response contributing to the pathophysiology of cardiovascular disease. This response is signaled in part by interleukin-6 (IL-6), a pleiotropic, pro-inflammatory cytokine. Phenotypic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Cytokine Receptor gp130

Share to Epigenesis, Genetic

Share to Heart Disease Risk Factors

Share to Inflammation

Share to Interleukin-6

Share to Receptors, Interleukin-6

Source

Open in PubMed Open full text

Identifiers

PMID: 40480020
DOI: 10.1016/j.atherosclerosis.2025.120219
PMCID: PMC12276907

Genes

IL6
IL6R
IL6ST
LYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease.PMID 40480020Read ↗

Genetically downregulated interleukin-6 signaling is associated with a favorable cardiometabolic profile: a phenome-wide association studySemantic proximity Read ↗

Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosisSemantic proximity Read ↗

Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on AtherosclerosisSemantic proximity Read ↗

Hypomethylation of interleukin-6 (IL-6) gene increases the risk of essential hypertension: a matched case-control study.Semantic proximity Read ↗

Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.Semantic proximity Read ↗

Association of IL-6 promoter polymorphism hotspots (- 174G/C and - 572G/C) with cardiovascular disease risk factors.Semantic proximity Read ↗

Hypomethylation of Interleukin-6 Promoter is Associated with the Risk of Coronary Heart Disease.Semantic proximity Read ↗

Blood-Based DNA Methylation Biomarkers to Identify Risk and Progression of Cardiovascular DiseaseSemantic proximity Read ↗

Interaction between SELP genetic polymorphisms with inflammatory cytokine interleukin-6 (IL-6) gene variants on cardiovascular disease in Chinese Han population.Semantic proximity Read ↗

Genome-wide association study of circulating interleukin 6 levels identifies novel loci.Semantic proximity Read ↗

Leveraging genetic data to investigate the effects of interleukin-6 receptor signalling on levels of 40 circulating cytokines.Semantic proximity Read ↗

A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.