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Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

2026-08-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Neuromelanin (NM) is a pigment that progressively accumulates with age in catecholaminergic neurons, particularly in the substantia nigra, ventral tegmental area, and locus coeruleus. These neuronal populations are especially vulnerable to degeneration in Parkinson’s disease (PD). Elevated intracellular NM levels have been linked to neurodegeneration and PD-like phenotypes i...

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Literature Corpus work
e920fec5-97cc-50e2-a8b7-46c59cabb4eb
DOI
10.64898/2026.08.03.742448
Open publication

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Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegenerationDOI 10.64898/2026.08.03.742448
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