Article

Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits

2023-08-08

Abstract excerpt

<h4>ABSTRACT</h4> One key limitation in developing effective treatments for neurodegenerative diseases is the lack of models accurately mimicking the complex physiopathology of the human disease. Humans accumulate with age the pigment neuromelanin inside neurons that synthesize catecholamines. Neurons reaching the highest neuromelanin levels preferentially degenerate in Parkinson’s, Alzheimer’s and apparently hea...

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Literature Corpus work: 648084b4-0177-5d7a-9b5e-7fa150cde560
DOI: 10.1101/2023.08.08.552400

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