Article

Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of Parkinson’s disease

2022-02-11

Abstract excerpt

<h4>ABSTRACT</h4> The lysosomal cysteine hydrolase N -acylethanolamine acid amidase (NAAA) deactivates the lipidderived mediator palmitoylethanolamide (PEA), an endogenous PPAR-α agonist that is critically involved in the control of inflammation and nociception. In this study, we asked whether NAAA-regulated PEA signaling might contribute to the pathogenesis of Parkinson’s disease (PD), a neurodegenerative disor...

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Literature Corpus work: 93f77874-7671-5330-8f73-0e2a764a1bca
DOI: 10.1101/2022.02.10.479850

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