Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease

1 Jan 2022

Abstract excerpt

Abstract Exposure to pesticides in humans increases the risk of Parkinson’s disease (PD), but the mechanisms remain poorly understood. To elucidate these pathways, we dosed C57BL/6J mice with a combination of the pesticides maneb and paraquat. Behavioral analysis revealed motor deficits consistent with PD. Single-cell RNA sequencing of substantia nigra pars compacta revealed both cell-type-specific genes and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Parkinson's Disease Mechanisms and Treatments
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36117858
DOI: 10.1515/tnsci-2022-0237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s diseasePMID 36117858Read ↗

Single cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s diseaseSemantic proximity Read ↗

Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s modelSemantic proximity Read ↗

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson’s disease mouse brainSemantic proximity Read ↗

Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in a rotenone rat model of Parkinson’s diseaseSemantic proximity Read ↗

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s diseaseSemantic proximity Read ↗

Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological RelevanceSemantic proximity Read ↗

Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson’s diseaseSemantic proximity Read ↗

Single cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging and diseaseSemantic proximity Read ↗

Dysregulation of Gene Expression in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Substantia NigraSemantic proximity Read ↗

A human single-cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson’s disease and neuropsychiatric disordersSemantic proximity Read ↗

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disordersSemantic proximity Read ↗

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.